产品货号：
Z35405
中文名称：
MTBP抗体
英文名称：
Anti-MTBP Antibody (Clone#PHL-1)
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MTBP Antibody (Clone#PHL-1) |
| 指标别名 | hMTBP;Mdm2 binding protein;MDM2BP;MTBP |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | MTBP |
| 克隆号 | PHL-1 |
| 抗体来源 | Mouse |
| 免疫原 | This protein A purified monoclonal antibody was produced by repeated immunizations with a recombinant amino-terminal HIS6X-tagged polypeptide corresponding to amino acid residues 667-812 of human MTBP protein. |
| 计算分子量 | 102kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This antibody is directed against human MTBP protein.The product was produced from clarified mouse ascetic fluid.A BLAST analysis was used to suggest reactivity with this protein from human (100% homology) and chimpanzee.Cross-reactivity with MTBP protein from mouse (77% homology) and chicken (79% homology) is unlikely due to the relatively low number of positive residues and high number of gaps within this sequence.Cross-reactivity with MTBP homologues from other sources has not been determined. |
| 浓度 | Neat N/A |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | The MDM2 onco-protein is over expressed in human cancer cells and it promotes tumorigenesis by directly blocking the function of the p53 tumor suppressor.Studies also indicate that MDM2 regulates cell proliferation via p53 independent mechanisms.MTBP (Mdm2 [Two] Binding Protein) was identified by a yeast two-hybrid screen as an MDM2 binding protein (1).MTBP has been reported to modulate cell cycle progression by a p53 independent mechanism and suppress MDM2-mediated p53 degradation when ectopically expressed in cells (1,2).The human MTBP gene localizes to 8q24 (3) and MTBP RNA is expressed in a wide range of tissues,with highest being in the thymus,testes and ovaries (1). |
| Uniprot ID | Q96DY7 |
| 基因名全称 | Mdm2-binding protein |
| 推荐稀释比 | ELISA:1:2,000 - 1:20,000 WB:1:200 - 1:2,000 |
相关搜索：MTBP抗体，MTBP单抗，Anti-MTBP Antibody (Clone#PHL-1)